The Bassoon Antibody: Alkaline Phosphatase from MyBioSource.com is a Rabbit Polyclonal antibody to Bassoon, and BSN. This antibody recognizes Human, Mouse, and Rat antigen. The Bassoon Antibody: Alkaline Phosphatase has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Background Info: Detects ~420kDa, corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected. No cross-reactivity to Piccolo.
Scientific Background: Bassoon (1) is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors